Title : Differential modulation of drug - induced structural and functional plasticity of dendritic spines

نویسندگان

  • Eric C. Miller
  • Lei Zhang
  • Benjamin W. Dummer
  • Desmond R. Cariveau
  • Horace Loh
  • Ping-Yee Law
  • Dezhi Liao
چکیده

157 words Introduction: 488 words

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Differential modulation of drug-induced structural and functional plasticity of dendritic spines.

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The “addicted” spine

Units of dendritic branches called dendritic spines represent more than simply decorative appendages of the neuron and actively participate in integrative functions of "spinous" nerve cells thereby contributing to the general phenomenon of synaptic plasticity. In animal models of drug addiction, spines are profoundly affected by treatments with drugs of abuse and represent important sub cellula...

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Structural plasticity of excitatory synapses is a vital component of neuronal development, synaptic plasticity, and behaviour. Abnormal development or regulation of excitatory synapses has also been strongly implicated in many neurodevelopmental, psychiatric, and neurodegenerative disorders. In the mammalian forebrain, the majority of excitatory synapses are located on dendritic spines, special...

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Signalling pathways underlying structural plasticity of dendritic spines

Synaptic plasticity, or changes in synaptic strength, is thought to underlie learning and memory. Imaging studies, mainly in brain slices, have revealed that long-term synaptic plasticity of excitatory synapses in hippocampal neurons is coupled with structural plasticity of dendritic spines, which is thought to be essential for inducing and regulating functional plasticity. Using pharmacologica...

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تاریخ انتشار 2012